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What's the difference between a GPS and a GPS with an expansion card? Look at the Garmin GPSMAP60 series, with and without the X designation.
The ones without the X do not have the micro-SD slot. They have enough onboard memory to give you map detail of one to three states, which can be limiting.
The X model comes with a 2GB card. It can hold an entire map of North America. Users also do not have the inconvenience of having to upload and download maps from a CD via USB.
Pick the product that meets your needs, though it may be to your advantage to have expandable memory and enough data for whatever situation you encounter.